非洲类人猿祖先基因组中重复片段的激增

A burst of segmental duplications in the genome of the African great ape ancestor

Tomas Marques-Bonet. A burst of segmental duplications in the genome of the African great ape ancestor. Nature 457, 877-881(2009)

1. most (80% or,55Mb) high-identity human segmental duplications arose after the divergence of the Old World monkey and hominoid lineages.
人的大部分重复片段都是在人－古猿分离后出现的。

2. Humans and chimpanzees show significantly more duplications than either macaque or orang-utan, with a large fraction being shared between chimpanzee and human.
人与黑猩猩有更多的重复片段，而且很多是相同的。

3. The genomic distribution of great-ape segmental duplications is highly nonrandom with the presence of ancestral duplications being a strong predictor of ‘new’, lineage-specific events.
类人猿重复片段的分布不是随机的，来自祖先的重复片段与自身特有的重复片段往往相邻。

4. We find a significant increase in both the number of events and base pairs in the human/African great-ape lineage when compared to macaque/Old World monkey lineage.
人－非洲类人猿分支的重复片段发生了显著增加。

5. The most significant burst of activity occurs in the common ancestor of human/chimpanzee and gorilla and after divergence of gorilla from the human–chimpanzee lineage
重复率增加最明显的是在人/黑猩猩与大猩猩的共同祖先与大猩猩的分支处。